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Home Bio/Med/Pharma

Anavex Life Sciences (NASDAQ: AVXL) Says Phase 2b/3 for ANAVEX2-73 Met Primary and Secondary Endpoints Reducing Cognative Decline in Patients with Early Alzheimer’s

by admin
December 2, 2022
in Bio/Med/Pharma
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Anavex Life Sciences NASDAQ AVXL Phase 2b/3 ANAVEX2-73 Spotlight Growth

Anavex Life Sciences NASDAQ AVXL Phase 2b/3 ANAVEX2-73 Spotlight Growth

Anavex Life Sciences Corp. (NASDAQ: AVXL) is engaged as a clinical-stage biopharmaceutical company, which is focused on the research and development of innovative therapeutics to treat neurodegenerative disorders such as Alzheimer’s, Parkinson’s, Rett Syndrome and more. Shares of the biopharma company are rallying 38% through early trading on Friday, December 2, 2022. Over the past three months, Anavex Life Sciences has seen average daily volume of 1.04 million shares. However, volume of 35.27 million shares or dollar volume of around $428.53 million, has already exchanged hands through early trading.

Shares of Anavex Life Sciences are gaining after the company announced results from its Phase 2b/3 clinical trial of ANAVEX2-73 for the treatment of mild cognitive impairment (MCI) from early stages of Alzheimer’s disease. The clinical trial results showed the drug candidate met primary and key secondary endpoints, which were determined from meaningful improvements in cognitive function as measured by ADAS-Cog, ADCS-ADL, and CDR-SB. The company says the next step is to meet with the FDA to discuss the clinical data and work on commercialization.

ANAVEX2-73 is an orally-administered, small-molecule activator of the sigma-1 receptor, which has shown the capability of restoring neural cell homeostasis and promoting of neuroplasticity. The Phase 2b/3 trial was a randomized, double-blind, multicenter, placebo-controlled study that enrolled 509 patients for the treatment of early Alzheimer’s disease over the course of 48 weeks.

In the trial, patients that were treated with ANAVEX2-73 were 84% more likely to have improved cognitive abilities as measured by ADAS-Cog score change of -0.50 or better from the baseline to the end of treatment when compared to the placebo group. On average, patients who saw improvements while taking the drug candidate saw an average ASAS-Cog cognition score of -4.03 points. This shows ANAVEX2-73 was 167% more effective in improving cognitive abilities compared to the placebo group.

“People living with Alzheimer’s disease desperately need new therapies and I am truly impressed with the outcome of this study, which demonstrated reversal of cognitive decline,” said A/Professor Stephen Macfarlane, FRANZCP, Head of Clinical Services at the Dementia Centre, HammondCare and Principal Investigator. “These results complement and are consistent with findings from the previously completed Alzheimer’s disease Phase 2a ANAVEX®2-73 trial, which also demonstrated therapeutic effect on cognition and function. ANAVEX®2-73 might be a very much needed solution for many patients with Alzheimer’s disease.”

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

Tags: Alzheimer'sAnavex Life Sciencesbiopharmabiopharmaceuticalsbiotechbiotech stocksclinical trialscommon stockday tradingdow jones todayemerging growthFDAFDA newsinvestinginvesting newsinvestmentmedicalmicrocap stocksNASDAQneurodegenerative diseasenewsParkinson's diseasepharmaceuticalsPhase 2b/3public companyrett syndromesmall cap companiessmall cap stockssmall capsSpotlight GrowthSpotlight Growth Stocksstock marketstock newsstocksstocks to watchtradingtreatmentwebull wallstreetbets
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