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Home Bio/Med/Pharma

Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT) Soars 60% After Entering Into Clinical Trial Agreement With Moffitt Cancer Center For Phase 1b/2 Trial of LB-100

by admin
August 21, 2018
in Bio/Med/Pharma
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Lixte Biotechnology Holdings Clinical Trials Agreement Moffitt Cancer Center News

Lixte Biotechnology Holdings Clinical Trials Agreement Moffitt Cancer Center News

Lixte Biotechnology Holdings, Inc. (OTCQB:M LIXT) is a biotech company that focuses on identifying enzyme targets for common serious illnesses and developing treatments. Shares of the biotechnology company soared 60% during trading on Tuesday, August 21, 2018. Over the past month, Lixte Biotechnology Holdings, Inc. has seen average daily volume of 14,163 shares. However, volume of 46,369 shares or dollar volume of $37,095, exchanged hands on Tuesday.

Shares of Lixte Biotechnology Holdings, Inc. surged on Tuesday after the company announced that it has entered into Clinical Trial Agreement and Exclusive License Agreement with Moffitt Cancer Center for conducting Phase 1b/2 trials for LB-100, which helps treat myelodysplastic syndrome (MDS). The treatment will specifically be geared towards patients with low or intermediate-1 risk MDS. Here is the full press release detailing of the clinical trial agreement:

Lixte Biotechnology Holdings, Inc. Press Release:

EAST SETAUKET, NY, Aug. 21, 2018 (GLOBE NEWSWIRE) — Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT) announced that it has entered into a Clinical Trial Agreement and Exclusive License Agreement with Moffitt Cancer Center to conduct a Phase 1b/2 study of the safety and therapeutic benefit of Lixte’s lead clinical compound, LB-100, in patients with myelodysplastic syndrome (MDS). The trial will enter low and intermediate-1 risk MDS patients, including those with del(5q) MDS who have failed or are intolerant of standard treatment.

Dr. John S. Kovach, founder and CEO of Lixte, said, “Certain cancers possessing unique genetic changes are vulnerable to inhibition of an enzyme, protein phosphatase 2A (PP2A), by LB-100. Among these is myelodysplastic syndrome (MDS), an increasingly common family of neoplastic diseases, especially in persons aged 65 and older. MDS is characterized by failure of the bone marrow often causing significant anemia and requiring frequent blood transfusions. In preclinical models of MDS, treatment with LB-100 inhibits the growth and/or induces the death of the abnormal blood cells. Cells of one variant of MDS, termed del(5q) MDS, are missing 50% of their PP2A activity rendering them sensitive to PP2A inhibition.”

Currently there is only one drug, lenalidomide, approved for the treatment of del(5q) MDS, and virtually all patients become resistant to this therapy.

“We are excited to embark on the clinical investigation of LB-100 in lower-risk MDS patients. If LB-100 proves to be effective in the clinic, it could be an important addition to the limited treatment options for patients failing standard treatment,” said David Sallman, M.D., assistant member of Moffitt’s Malignant Hematology Department.

About Lixte Biotechnology Holdings, Inc.
Lixte is a biotech company that identifies enzyme targets associated with serious common diseases and then designs novel compounds to attack those targets. Lixte’s product pipeline is primarily focused on inhibitors of protein phosphatases, used alone and in combination with cytotoxic agents and immune checkpoint blockers.

About Moffitt Cancer Center
Moffitt is dedicated to one lifesaving mission: to contribute to the prevention and cure of cancer. The Tampa-based facility is one of only 49 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s scientific excellence, multidisciplinary research, and robust training and education. Moffitt is a Top 10 cancer hospital and has been nationally ranked by U.S. News & World Report since 1999. Moffitt devotes more than 2 million square feet to research and patient care. Moffitt’s expert nursing staff is recognized by the American Nurses Credentialing Center with Magnet® status, its highest distinction. With more than 6,000 team members, Moffitt has an economic impact in the state of $2.1 billion. For more information, call 1-888-MOFFITT (1-888-663-3488), visit MOFFITT.org, and follow the momentum on Facebook, Twitter and YouTube.

Forward-Looking Statements
This announcement contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, and Section 21E of the Securities Exchange Act of 1934. For example, statements regarding the Company’s financial position, business strategy and other plans and objectives for future operations, and assumptions and predictions about future product demand, supply, manufacturing, costs, marketing and pricing factors are all forward-looking statements. These statements are generally accompanied by words such as “intend,” anticipate,” “believe,” “estimate,” “potential(ly),” “continue,” “forecast,” “predict,” “plan,” “may,” “will,” “could,” “would,” “should,” “expect” or the negative of such terms or other comparable terminology. The Company believes that the assumptions and expectations reflected in such forward-looking statements are reasonable, based on information available to it on the date hereof, but the Company cannot provide assurances that these assumptions and expectations will prove to have been correct or that the Company will take any action that the Company may presently be planning. However, these forward-looking statements are inherently subject to known and unknown risks and uncertainties. Actual results or experience may differ materially from those expected or anticipated in the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, regulatory policies, available cash, research results, competition from other similar businesses, and market and general economic factors. This discussion should be read in conjunction with the Company’s filings with the United States Securities and Exchange Commission at http://www.sec.gov/edgar.shtml.

Tags: biopharmaceuticalsbiotechclinical trialscommon stockemerging growthinvestinginvestmentMDSmedicalmicrocap stocksMoffitt Cancer CenterMyelodysplastic syndromenewsotc marketsotc stockspharmaceuticalspublic companysalesservicessmall cap companiessmall cap stockssmall capsSpotlight GrowthSpotlight Growth Stocksstock marketstockstradingtreatment
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